Abcam/Recombinant human GSK3 beta protein (Active) (ab60863)/1/ab60863,Abcam,,Abcam,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Abcam/Recombinant human GSK3 beta protein (Active) (ab60863)/1/ab60863

产品编号：ab60863

市场价：¥0.00

场地：美国(厂家直采)

产品分类：蛋白类>多肽>多肽合成>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： Abcam

公司：Abcam

公司分类：

商品介绍

Product name
Recombinant human GSK3 beta protein (Active)See all GSK3 beta proteins and peptides
Biological activity
148nmol/min/mg
Purity
>75% Densitometry.
Expression system
Baculovirus infected Sf9 cells
Accession
P49841
Protein length
Full length protein
Animal free
No
Nature
Recombinant
- Species
  Human
- Predicted molecular weight
  73 kDa including tags
- Tags
  GST tag N-Terminus
- Additional sequence information
  (Genbank Number NM_002093)

Related Products
- Anti-GSK3 beta antibody [Y174] (ab32391)
Substrate reagent
- Glycogen synthase 1/GYS1 peptide (ab204860)

Our Abpromise guarantee covers the use ofab60863in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications
SDS-PAGE
Functional Studies
Western blot
Form
Liquid
Additional notes
ab204860 (Glycogen synthase 1 peptide) can be utilized as a substrate for assessing kinase activity.
Concentration information loading...

Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50Constituents: 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.307% Glutathione
This product is an active protein and may elicit a biological response in vivo, handle with caution.

Alternative names
- Glycogen Synthase Kinase 3 Beta
- Glycogen synthase kinase-3 beta
- GSK 3 beta
- GSK-3 beta
- GSK3B
- GSK3B_HUMAN
- GSK3beta isoform
- Serine/threonine-protein kinase GSK3B
see all
Function
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
Tissue specificity
Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain.
Post-translationalmodifications
Phosphorylated by AKT1 and ILK1. Activated by phosphorylation at Tyr-216.
Cellular localization
Cytoplasm. Nucleus. Cell membrane. The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
Target information above from: UniProt accessionP49841The UniProt ConsortiumThe Universal Protein Resource (UniProt) in 2010Nucleic Acids Res. 38:D142-D148 (2010).
Information by UniProt

品牌介绍

Abcam 位于英国的剑桥科学园，成立于1998年，专门生产和分销研究型抗体。在线目录 (www.abcam.cn) 已有超过 120,000 种抗体和试剂，并不断添加，供应予全球百多个国家。
为使研究员更容易找到蛋白质研究试剂产品，在2011并购了美国的 MitoSciences 公司，加强了免疫分析方面的产品供应；同年也并购了英国的 Ascent Scientific 公司，开展了生化试剂的供应。在2012年并购了美国的 Epitomics 公司，成为一家有领导地位的 RabMAbs® 供应商。
Abcam 的目标是给世界上最好的抗体建立最大的在线目录，为各地科学家提供尖端产品，成为各国科学界的重要伙伴，为所有产品提供技术支持来使客户获得预期的结果，为提供高质量的抗体来指向尽可能多的靶蛋白，尽所能在尽可能多的应用和物种中检测每种抗体。
Abcam 专注于特定的研究领域，包括肿瘤研究、心血管研究、染色质和基因调控研究、免疫学、内参对照、微生物学、神经科学、细胞核信号转导研究、RNAi 研究、干细胞研究、亚细胞标记物等。

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