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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Abcam/Recombinant human IGF1 protein (Active) (ab270062)/1/Active) (ab270062
产品编号:Active)(ab270062
市  场 价:¥0.00
场      地:美国(厂家直采)
产品分类: 蛋白类>多肽>多肽合成>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:待定
品      牌: Abcam
公      司:Abcam
公司分类:
Abcam/Recombinant human IGF1 protein (Active) (ab270062)/1/Active) (ab270062
商品介绍

Description

  • Product name

    Recombinant human IGF1 protein (Active)See all IGF1 proteins and peptides
  • Biological activity

    Fully biologicaly active as determined by dose-depended proliferation of MCF-7 cells.

    ED50 is ≤ 0.9 ng/mL, corresponding to a specific activity of 1.11 x 106 units/mg.

  • Purity

    >= 95% Immunogen affinity purified.Purity by HPLC >=95%.
  • Endotoxin level

    <>
  • Expression system

    HEK 293 cells
  • Accession

    P05019
  • Protein length

    Full length protein
  • Animal free

    Yes
  • Carrier free

    Yes
  • Nature

    Recombinant
    • Species

      Human
    • Sequence

      GP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSA
    • Predicted molecular weight

      8 kDa
    • Molecular weight information

      M - 2.84 Da (Calculated mass 7711.84 Da)GP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSA
    • Amino acids

      49 to 118
    • Additional sequence information

      N-terminal glycineFull-length mature chain lacking the signal peptide and both pro-peptides.

Associated products

    Specifications

    Our Abpromise guarantee covers the use ofab270062in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Cell Culture

      SDS-PAGE

      HPLC

      Mass Spectrometry

      Functional Studies

    • Form

      Lyophilized
    • Additional notes

      This protein is filter sterilized prior to aliquoting and lyophilization. All aliquoting and lyophilization steps are performed in a sterile environment

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at Room Temperature. Store at Room Temperature.

      Information available upon request.

      This product is an active protein and may elicit a biological response in vivo, handle with caution.

    • Reconstitution
      Reconstitute with phosphate buffered saline.Store lyophilized form at room temperature. Reconstitute, aliquot and store at -80°C for 12 months or +4°C for 1 week.Avoid repeated freeze-thaw.

    General Info

    • Alternative names

      • IBP1
      • IGF I
      • IGF IA
      • IGF IB
      • IGF-I
      • Igf1
      • IGF1_HUMAN
      • IGF1A
      • IGFI
      • IGFIA
      • Insulin like growth factor 1
      • Insulin like growth factor 1 (somatomedin C)
      • Insulin like growth factor IA
      • Insulin like growth factor IB
      • Insulin-like growth factor I
      • Mechano growth factor
      • MGF
      • OTTHUMP00000195080
      • OTTHUMP00000195081
      • OTTHUMP00000195082
      • OTTHUMP00000195083
      • OTTHUMP00000195084
      • Somatomedia C
      • Somatomedin C
      • Somatomedin-C
      see all
    • Function

      The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.
    • Involvement in disease

      Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
    • Sequence similarities

      Belongs to the insulin family.
    • Cellular localization

      Secreted.
    • Information by UniProt
    品牌介绍

    Abcam 位于英国的剑桥科学园,成立于1998年,专门生产和分销研究型抗体。在线目录 (www.abcam.cn) 已有超过 120,000 种抗体和试剂,并不断添加,供应予全球百多个国家。
    为使研究员更容易找到蛋白质研究试剂产品,在2011并购了美国的 MitoSciences 公司,加强了免疫分析方面的产品供应;同年也并购了英国的 Ascent Scientific 公司,开展了生化试剂的供应。在2012年并购了美国的 Epitomics 公司,成为一家有领导地位的 RabMAbs® 供应商。
    Abcam 的目标是给世界上最好的抗体建立最大的在线目录,为各地科学家提供尖端产品,成为各国科学界的重要伙伴,为所有产品提供技术支持来使客户获得预期的结果,为提供高质量的抗体来指向尽可能多的靶蛋白,尽所能在尽可能多的应用和物种中检测每种抗体。
    Abcam 专注于特定的研究领域,包括肿瘤研究、心血管研究、染色质和基因调控研究、免疫学、内参对照、微生物学、神经科学、细胞核信号转导研究、RNAi 研究、干细胞研究、亚细胞标记物等。

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