Abcam/Recombinant Human Interferon gamma protein (Active) (ab259377)/1/Active) (ab259377,Abcam,,Abcam,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Abcam/Recombinant Human Interferon gamma protein (Active) (ab259377)/1/Active) (ab259377

产品编号：Active)(ab259377

市场价：¥0.00

场地：美国(厂家直采)

产品分类：蛋白类>多肽>多肽合成>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： Abcam

公司：Abcam

公司分类：

商品介绍

Product name
Recombinant Human Interferon gamma protein (Active)See all Interferon gamma proteins and peptides
Biological activity
Fully biologically active when compared to standard. The ED₅₀ as determined by the dose-dependant Killing/apoptosis of HT-29 cells is 0.34 ng/mL corresponding to a Specific Activity of 2.94 x 10⁶IU/mg.
Purity
>= 95% SDS-PAGE.>= 95 % HPLC.
Endotoxin level
<>
Expression system
HEK 293 cells
Accession
P01579
Protein length
Full length protein
Animal free
Yes
Carrier free
Yes
Nature
Recombinant
- Species
  Human
- Sequence
  QDPYVQEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIV SFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSV TDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFRGRRASQ
- Predicted molecular weight
  17 kDa
- Amino acids
  24 to 166
- Additional sequence information
  Full length protein including propeptide. N-terminal Glycine
Description
Recombinant human Interferon gamma protein (Active)

Our Abpromise guarantee covers the use ofab259377in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications
Mass Spectrometry
Cell Culture
HPLC
SDS-PAGE
Functional Studies
Form
Lyophilized
Additional notes
This protein is filter sterilised prior to aliquoting and lyophilisation. All aliquoting and lyophilisation steps are performed in a sterile environment
Concentration information loading...

Stability and Storage
Shipped at Room Temperature. Store at Room Temperature.
Information available upon request.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitution
Reconstitute with Phosphate Buffered Saline.Reconstituted protein stable at -80C for 12 months or 4C for 1 week.

Alternative names
- IF 1
- IFG
- IFI
- IFN gamma
- IFN immune
- IFN, immune
- IFN-gamma
- IFNG
- IFNG_HUMAN
- Immune interferon
- Interferon gamma
- Type II Interferon
see all
Function
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Tissue specificity
Released primarily from activated T lymphocytes.
Involvement in disease
In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
Sequence similarities
Belongs to the type II (or gamma) interferon family.
Post-translationalmodifications
Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
Cellular localization
Secreted.
Target information above from: UniProt accessionP01579The UniProt ConsortiumThe Universal Protein Resource (UniProt) in 2010Nucleic Acids Res. 38:D142-D148 (2010).
Information by UniProt

品牌介绍

Abcam 位于英国的剑桥科学园，成立于1998年，专门生产和分销研究型抗体。在线目录 (www.abcam.cn) 已有超过 120,000 种抗体和试剂，并不断添加，供应予全球百多个国家。
为使研究员更容易找到蛋白质研究试剂产品，在2011并购了美国的 MitoSciences 公司，加强了免疫分析方面的产品供应；同年也并购了英国的 Ascent Scientific 公司，开展了生化试剂的供应。在2012年并购了美国的 Epitomics 公司，成为一家有领导地位的 RabMAbs® 供应商。
Abcam 的目标是给世界上最好的抗体建立最大的在线目录，为各地科学家提供尖端产品，成为各国科学界的重要伙伴，为所有产品提供技术支持来使客户获得预期的结果，为提供高质量的抗体来指向尽可能多的靶蛋白，尽所能在尽可能多的应用和物种中检测每种抗体。
Abcam 专注于特定的研究领域，包括肿瘤研究、心血管研究、染色质和基因调控研究、免疫学、内参对照、微生物学、神经科学、细胞核信号转导研究、RNAi 研究、干细胞研究、亚细胞标记物等。

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