Abcam/Recombinant human TNF alpha protein (Active) (ab259410)/1/Active) (ab259410,Abcam,,Abcam,+,,Array.Array蚂蚁淘厂家直采.

产品名称：Abcam/Recombinant human TNF alpha protein (Active) (ab259410)/1/Active) (ab259410

产品编号：Active)(ab259410

市场价：¥0.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： Abcam

公司：Abcam

公司分类：

商品介绍

Product name
Recombinant human TNF alpha protein (Active)See all TNF alpha proteins and peptides
Biological activity
Fully biologically active when compared to standard. The ED₅₀ as determined by the dose-dependant Killing/apoptosis of L-929 cells is 0.71ng/mL corresponding to a Specific Activity of 1.41 x 10⁶IU/mg.
Purity
>= 95% Immunogen affinity purified.>= 95 % HPLC.
Endotoxin level
<>
Expression system
HEK 293 cells
Accession
P01375
Protein length
Full length protein
Animal free
Yes
Carrier free
Yes
Nature
Recombinant
- Species
  Human
- Sequence
  VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVV PSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSP CQRETPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQV YFGIIAL
- Predicted molecular weight
  17 kDa
- Amino acids
  77 to 233
- Additional sequence information
  Full length mature chain soluble form. N-terminal glycine.

Our Abpromise guarantee covers the use ofab259410in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Applications
Cell Culture
Functional Studies
Mass Spectrometry
HPLC
SDS-PAGE
Form
Lyophilized
Additional notes
This protein is filter sterilised prior to aliquoting and lyophilisation. All aliquoting and lyophilisation steps are performed in a sterile environment
Concentration information loading...

Stability and Storage
Shipped at Room Temperature. Store at Room Temperature.
Information available upon request.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Reconstitution
Reconstitute with Phosphate Buffered Saline.Reconstituted protein stable at -80C for 12 months or 4C for 1 week.

Alternative names
- APC1
- APC1 protein
- Cachectin
- DIF
- Differentiation inducing factor
- Macrophage cytotoxic factor
- Tnf
- TNF superfamily member 2
- TNF superfamily, member 2
- TNF, macrophage derived
- TNF, monocyte derived
- TNF-a
- TNF-alpha
- TNFA
- TNFA_HUMAN
- TNFSF2
- Tumor necrosis factor
- Tumor necrosis factor (TNF superfamily member 2)
- Tumor necrosis factor alpha
- Tumor necrosis factor ligand superfamily member 2
- Tumor Necrosis Factor, Membrane Form
- Tumor necrosis factor, soluble form
see all
Function
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Involvement in disease
Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
Sequence similarities
Belongs to the tumor necrosis factor family.
Post-translationalmodifications
The soluble form derives from the membrane form by proteolytic processing.The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
Cellular localization
Secreted and Cell membrane.
Target information above from: UniProt accessionP01375The UniProt ConsortiumThe Universal Protein Resource (UniProt) in 2010Nucleic Acids Res. 38:D142-D148 (2010).
Information by UniProt

品牌介绍

Abcam 位于英国的剑桥科学园，成立于1998年，专门生产和分销研究型抗体。在线目录 (www.abcam.cn) 已有超过 120,000 种抗体和试剂，并不断添加，供应予全球百多个国家。
为使研究员更容易找到蛋白质研究试剂产品，在2011并购了美国的 MitoSciences 公司，加强了免疫分析方面的产品供应；同年也并购了英国的 Ascent Scientific 公司，开展了生化试剂的供应。在2012年并购了美国的 Epitomics 公司，成为一家有领导地位的 RabMAbs® 供应商。
Abcam 的目标是给世界上最好的抗体建立最大的在线目录，为各地科学家提供尖端产品，成为各国科学界的重要伙伴，为所有产品提供技术支持来使客户获得预期的结果，为提供高质量的抗体来指向尽可能多的靶蛋白，尽所能在尽可能多的应用和物种中检测每种抗体。
Abcam 专注于特定的研究领域，包括肿瘤研究、心血管研究、染色质和基因调控研究、免疫学、内参对照、微生物学、神经科学、细胞核信号转导研究、RNAi 研究、干细胞研究、亚细胞标记物等。

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