Abcam/PRX Pathway (TRX, TXNRD1, PRX1) Western Blot Cocktail (ab184868)/200 µl/ab184868,Abcam,,Abcam,+,,Array.Array蚂蚁淘厂家直采.

产品名称：Abcam/PRX Pathway (TRX, TXNRD1, PRX1) Western Blot Cocktail (ab184868)/200 µl/ab184868

产品编号：ab184868

市场价：¥0.00

场地：美国(厂家直采)

产品分类：蛋白类>聚合物>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：待定

品牌： Abcam

公司：Abcam

公司分类：

商品介绍

Product name
PRX Pathway (TRX, TXNRD1, PRX1) Western Blot Cocktail
Sample type
Cell Lysate
Species reactivity
Reacts with:Mouse, Rat, Human
Product overview
The PRX pathway Western blot cocktail is designed to determine the relative abundance of several important proteins involved in the thioredoxin redox pathway.
Thioredoxin (TRX) is a small enzyme (12kDa) that facilitates the reduction of other enzymes via cysteine thiol-disulfide exchange. Thioredoxin is used by cells to reduce ROS amounts and in redox signaling processes. Thioredoxin reductase 1 (TXNRD1) is found in the cytoplasm and possesses glutaredoxin and thioredoxin reductase activity. TXNRD1 utilizes its redox-active disulfide bond to reduce oxidized thioredoxin. Also involved in the thioredoxin redox pathway and additionally shown to be upregulated in a variety of cancers is the relatively abundant peroxiredoxin 1 (PRX1). Peroxiredoxin 1 is an antioxidant enzyme that helps regulate peroxide levels and is involved in redox signaling. Peroxiredoxin 1’s activity is regenerated after being reduced by thioredoxin.
Notes
These three readouts are easily resolved by Western blot given their different molecular weights. As all primary antibodies in the WB cocktail are rabbit antibodies, an anti-rabbit secondary should be used for detection.
Expected and observed MWs:Thioredoxin: 12 kDaThioredoxin Reductase 1: 55 kDaPeroxiredoxin 1: 22 kDa
Tested applications
Suitable for:WBmore details

Storage instructions
Store at -20°C. Please refer to protocols.
Components 200 µl
250X PRX Pathway (TRX, TXNRD1, PRX1) Western Blot Cocktail 1 x 200µl
Research areas
- Kits/ Lysates/ Other
- Kits
- Antibody Cocktails
- PRX
Database links
- Entrez Gene:5052 Human
- Entrez Gene:7295 Human
- Entrez Gene:7296 Human
- Entrez Gene:18477 Mouse
- Entrez Gene:50493 Mouse
- Entrez Gene:117254 Rat
- Entrez Gene:58819 Rat
- SwissProt:P10599 Human
- SwissProt:Q16881 Human
- SwissProt:Q06830 Human
- SwissProt:P10639 Mouse
- SwissProt:P11232 Mouse
- SwissProt:P35700 Mouse
- SwissProt:Q9JMH6 Mouse
- SwissProt:Q63716 Rat
- SwissProt:O89049 Rat
see all

Components	200 µl
250X PRX Pathway (TRX, TXNRD1, PRX1) Western Blot Cocktail	1 x 200µl

品牌介绍

Abcam 位于英国的剑桥科学园，成立于1998年，专门生产和分销研究型抗体。在线目录 (www.abcam.cn) 已有超过 120,000 种抗体和试剂，并不断添加，供应予全球百多个国家。
为使研究员更容易找到蛋白质研究试剂产品，在2011并购了美国的 MitoSciences 公司，加强了免疫分析方面的产品供应；同年也并购了英国的 Ascent Scientific 公司，开展了生化试剂的供应。在2012年并购了美国的 Epitomics 公司，成为一家有领导地位的 RabMAbs® 供应商。
Abcam 的目标是给世界上最好的抗体建立最大的在线目录，为各地科学家提供尖端产品，成为各国科学界的重要伙伴，为所有产品提供技术支持来使客户获得预期的结果，为提供高质量的抗体来指向尽可能多的靶蛋白，尽所能在尽可能多的应用和物种中检测每种抗体。
Abcam 专注于特定的研究领域，包括肿瘤研究、心血管研究、染色质和基因调控研究、免疫学、内参对照、微生物学、神经科学、细胞核信号转导研究、RNAi 研究、干细胞研究、亚细胞标记物等。

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